Health Condition 1: N460- Azoospermia Health Condition 2: null- Idiopathic obstructive Azoospermia
Conditions
Interventions
Intervention1: Bilateral Vaso-epididymostomy: Vaso-epididymostomy is a standrad operation for patients with Idiopathic obstructive azoospermia. It will be done on bilateral vas deferens in patients
Co
Sponsors
AIIMS
Eligibility
Inclusion criteria
Inclusion criteria: 1.Clinical examination on patients excluded bilateral vas aplasia. Normal semen volume, presence of fructose and absolute azoospermia was conï¬?rmed on at least two semen samples. No patient had had a previous vasectomy, inguinal or scrotal surgery, trauma, or inï¬?ammation/infection of the testis. Fine-needle (23 G) aspiration cytology was performed on both testes, the aspirate was stained with Giemsa stain and considered to show â??normalâ?? spermatogenesis if the slide revealed many mature sperm 2.Both sides are suitable for surgery 3.Patient willing for bilateral surgery if the randomization chart places him in the bilateral category
Exclusion criteria
Exclusion criteria: 1.Patients with previous failed vaso- epididymal anastomosis 2.Patients who, during surgery, are found to be not suitable for reconstruction or where the surgery is abandoned.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Patency rate (determined by appearance of sperm in the ejaculate), complication rate and operative time after unilateral versus bilateral Vaso-epididymal anastomosisTimepoint: Patients will be asked to maintain sexual abstinence for 6 weeks. Semen analysis will be done at 6 weeks following surgery followed by repeat analysis at 12 weeks and then at every subsequent 3 months intervals for a follow up period of 12 months or till sperm are seen in the ejaculate, whichever is earlier | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Comparison of patients characteristics (age, duration of infertility, FSH and epididymal sperm motility) between the two groupsTimepoint: At the time of randomization;2. Identify factors among bilateral surgery patients which suggest better patency than unilateral surgeryTimepoint: At the time of enrollment | — |
Countries
India
Contacts
Public ContactDr Nishant Gurnani
AIIMS
Outcome results
None listed