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To assess the effect of two different doses of morphine when added to bupivacaine for spinal anaesthesia in patients undergoing total knee replacement

Assessment of the efficacy of two different doses (100mcg and 200 mcg)of intrathecal morphine when added to bupivacaine for post operative analgesia after total knee replacement..a randomised controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/08/020914
Enrollment
120
Registered
2019-08-26
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Intrathecal morphine 100microgram: Duration of postoperative pain relief Control Intervention1: Intrathecal morphine 200microgram: Duration of postoperative pain relief

Sponsors

Govt TD Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Age group more than 40 yrs 2) Patients presenting for elective total Knee replacement. 3) ASA 1-3

Exclusion criteria

Exclusion criteria: 1) Those patients having revision surgery 2) Patients for whom spinal anesthesia is contraindicated 3) History of hypersensitivity to opioid medications 4) Chronic pain syndrome or current regular opioid use

Design outcomes

Primary

MeasureTime frame
Efficacy in prolonging duration of analgesia as assessed by VAS score at rest and on movementTimepoint: 2hr,4hr,6hr,8 hr,10 hr,12hr,18 hr,24 hr—

Secondary

MeasureTime frame
Study of side effects like sedation,nausea,vomiting and pruritusTimepoint: 2,4,6,8,10,12,18,24 hrs—

Countries

India

Contacts

Public ContactNanna R Chandran

Department of Anaesthesiology,Govt T D Medical College,Alappuzha

drdeepagsaji@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026