Prevention of postoperative nausea and vomiting and reduction of analgesic requirement by use of dexamethasone, dexmedetomidine and combination of dexamethasone-dexmedetomidine.

Comparision of intraperitoneal dexamethasone, dexmedetomidine and dexamethasone-dexmedetomidine combination on postoperative nausea and vomiting and analgesics requirement after gynecological laparoscopy: a randomized clinical trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/08/020888

Enrollment

160

Registered

2019-08-26

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N859- Noninflammatory disorder of uterus, unspecified

Interventions

Intervention1: Dexamethasone: Dexamethasone 8 mg through intraperitoneal route at the end of the procedure, before laparoscopic trocar withdrawal, in total volume of 20 ml Intervention2: Dexmedetomidi

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA grade I and II 2. Scheduled for laparoscopic gynaecological surgery under general anesthesia

Exclusion criteria

Exclusion criteria: 1.Known allergy to study drugs 2.Use of antiemetic drugs within 24 hours of surgery 3.Morbid obesity( body mass index >40) 4.Chronic use of opioids 5.Patients with hepatic, renal or cardiovascular dysfunction 6.Psychiatric patients

Design outcomes

Primary

Measure	Time frame
Incidence of post operative nausea and vomitingTimepoint: 24 hr postoperatve period	—

Secondary

Measure	Time frame
Total consumption of paracetamolTimepoint: 24 hr postoperative period	—

Countries

India

Contacts

Public ContactDR Vinit Kumar Srivastava

Apollo Hospitals Bilaspur

poojasgupta125@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026