Health Condition 1: H160- Corneal ulcer
Conditions
Interventions
Intervention1: Topical miltefossine: Patients of Acanthamoeba keratitis
Route of administration is topical every hourly for 1 week followed by every 2 hourly.
Control Intervention1: Not Applicable:
Sponsors
LV Prasad Eye Institute
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age equal to or more than 18 years. 2) Male or female 3) Stromal infiltrate size between 4) Corneal scraping positive for Acanthamoeba cysts in direct smear examination by any one or more of the methods used.
Exclusion criteria
Exclusion criteria: 1) The corneal scrapings are negative for Acanthamoeba. 2)The patient has a history of allergy to Miltefosine 3) The cornea or sclera has been perforated or perforation is impending. 4)The unaffected eye is legally blind. . 5)The patient is known to be HIV positive or diabetic. 6)The initial culture shows significant growth of bacteria ( >10 colonies) or fungus. 7)Both eyes are infected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Size of the infiltrate and inflammatory signsTimepoint: Size of the infiltrate and inflammatory signs. complete Resolution of infection or resolving infection | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of patients went to therapeutic TreatmentTimepoint: 1 month | — |
Countries
India
Contacts
Public ContactDrBhupesh Bagga
LV Prasad Eye Institute
Outcome results
None listed