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To compare the efficacy of two types of anesthesia techniques on post operative pain relief in patients undergoing breast cancer study

To compare the efficacy of opioid free general anesthesia with opioid based general anesthesia on post operative morphine consumption in patients undergoing breast cancer surgery: a prospective randomized control study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/08/020865
Enrollment
100
Registered
2019-08-23
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C506- Malignant neoplasm of axillary tail of breast Health Condition 2: C509- Malignant neoplasm of breast of unspecified site Health Condition 3: C501- Malignant neoplasm of central portion of breast Health Condition 4: C503- Malignant neoplasm of lower-innerquadrant of breast Health Condition 5: C505- Malignant neoplasm of lower-outerquadrant of breast Health Condition 6: C500- Malignant neoplasm of nipple and areola Health Condition 7: C508- Malignant neoplasm of overlappi

Interventions

Intervention1: Opioid free general anesthesia: All patients in this group will receive Erector spinae plane block before induction. Dexmedetomidine infusion 0.5 mcg/kg/hr will be started 10 minutes pr

Sponsors

Dr BRA IRCH AIIMS New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18-7O years 2. ASA I and II 3. Patients posted for breast cancer surgery 4. Patients giving written informed consent to participate in the study

Exclusion criteria

Exclusion criteria: 1. Patient refusal 3. Patients with BMI > 35kg/m2 4. Patient with infection at the site of injection 5. Coagulopathy 6. Spine deformity 7. Drug addicts or history of opioid dependence 8. Patients with history of allergy to opioids,local anaesthetics or magnesium. 9. Patients with myopathy or neuropathy.

Design outcomes

Primary

MeasureTime frame
Analgesic efficacy in terms of total postoperative morphine consumption in 24 hoursTimepoint: 24 hours—

Secondary

MeasureTime frame
Neutrophil-Lymphocyte ratio (NLR), Platelet Lymphocyte Ratio (PLR) and number of Natural Killer Cells (NKCs), T helper cells, cytotoxic T cellsTimepoint: 1 day prior to surgery, immediate post operative period, 24 hours post operatively;NRS pain scoreTimepoint: 0,30 min, 1hr. 2hr, 6hr, 24hr post operatively.;Patient satisfaction in a likert scale of 1-7Timepoint: 24 hours post operatively;Side effects if anyTimepoint: 0, 30 min, 1 hr, 2 hr, 6 hr, 24 hr post operatively—

Countries

India

Contacts

Public ContactRiniki Sarma

Dr BRA IRCH

drnishkarsh@rediffmail.com9013310014

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026