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Comparison of Norepinephrine infusion and bolus regimens in treatment of spinal induced hypotension during Cesarean delivery

Comparison of Norepinephrine Infusion and Bolus Regimens During Cesarean Delivery Under Spinal Anesthesia: A Randomized Clinical Trial - NEIB

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/08/020849
Enrollment
50
Registered
2019-08-22
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: group B: Group B patients will receive 4mcg of norepinephrine as intravenous bolus whenever the mean arterial pressure drops below 20% of baseline. Control Intervention1: GROUPI: GROUP

Sponsors

Amrita Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Elective CS under spinal anaesthesia 2. Normal singleton pregnancy beyond 36 weeks gestation 3. ASA physical status 1 or 2 4. Weight 50-100 kg 5. Height 150-180 cm

Exclusion criteria

Exclusion criteria: 1.Allergy or hypersensitivity to norepinephrine 2.Any hypertensive disorders of pregnancy 3.Cardiovascular or cerebrovascular disease 4.Fetal abnormalities

Design outcomes

Primary

MeasureTime frame
To compare the total dose of norepinephrine required to maintain maternal blood pressure when used as bolus or infusion in patients undergoing caesarean section under spinal anaesthesia.Timepoint: intraoperative period

Secondary

MeasureTime frame
To compare the effects of bolus versus infusion of norepinephrine on incidence of bradycardia, hypertension ,nausea and vomiting in mother and foetal outcomes as assessed by APGAR score and umbilical vein pH.Timepoint: intraoperative period

Countries

India

Contacts

Public ContactNitu PV

Amrita Institute of medical Sciences

nituveesundeep@gmail.com09495962020

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026