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A study comprising of chemotherapy and radiotherapy before the surgery of locally advanced rectal cancer.

Neoadjuvant chemotherapy with short course radiotherapy for locally advanced rectal cancer: a pilot study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/08/020847
Enrollment
15
Registered
2019-08-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C20- Malignant neoplasm of rectum

Interventions

Intervention1: neoadjuvant chemotherapy (CAPOX) and neoadjuvant short course radiotherapy in locally advanced rectal cancer: Once the patient has been enrolled in the trial , they will receive 3 cycle

Sponsors

AIIMS New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient with locally advanced adenocarcinoma of the rectum, stage IIA and above, i.e, T3 and above or any T with positive lymph node

Exclusion criteria

Exclusion criteria: 1.Age less than 18 years and above 65 years 2. Metastatic rectal carcinoma 3.Recurrent rectal carcinoma 4.Concomitant malignancies 5.Rectal tumor above 10 cm from anal verge on rigid sigmoidoscopy 6.Impairment of renal function test 7.Previous history of pelvic radiation 8.Pregnancy/ lactation 9.Concurrent uncontrolled medical conditions 10.Inflammatory bowel disease 11.Unfit for surgery 12.Contraindications for MRI

Design outcomes

Primary

MeasureTime frame
Tumor regression after neoadjuvant multidrug chemotherapy and neoadjuvant short course radiotherapy. Regression will be assessed radiologically and pathologically. Timepoint: December, 2021—

Secondary

MeasureTime frame
ï?? Compliance to neoadjuvant chemotherapy and neoadjuvant short course radiotherapy ï?? Post operative surgical complicationsTimepoint: Upto November 2021—

Countries

India

Contacts

Public ContactDr Catherine Halam

AIIMS, New Delhi.

dr_hkb75@yahoo.com7838621462

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026