Health Condition 1: S00-T88- Injury, poisoning and certain other consequences of external causes
Conditions
Interventions
Intervention1: Leukoreduced blood component transfusion: Blood components will be leucofiltered during processing and storage using commercially available leukofilter for blood components
Control Inte
Sponsors
AIIMS
Eligibility
Inclusion criteria
Inclusion criteria: all patients above 18 years of age receiving RBC transfusion within 24 hours of admission.
Exclusion criteria
Exclusion criteria: 1) Patients with an anticipated survival of less than 48 hours 2) Isolated head injury patients 3) Received blood transfusion elsewhere 4) Presence of active infection 5) Pregnant females and jail inmates will be not eligible for randomization. 6) Patient with Rh(D) negative groups
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome will include development of all hospital acquired infections [urinary tract infections (UTI), bloodstream infections (BSI), pneumonia (PNEU), ventilator-associated infections (VAE), and surgical site infections (SSI)] as defined by CDC/NHSN surveillance definitionTimepoint: Till the time of discharge or hospital death whichever is earlier | — |
Secondary
| Measure | Time frame |
|---|---|
| Monitoring of the quantitative levels of sTREM and procalcitonin measured in all patients. Proportion of patient showing values above cut-off limit shall be considered as having infectionTimepoint: Till the time of discharge or death whichever is earlier | — |
Countries
India
Contacts
Public ContactDr Rahul Chaurasia
All India Institute of Medical Sciences
Outcome results
None listed