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A clinical trial to study the effect of adding dexmedetomidine to ropivacaine scalp block to attenuate the hemodynamic response to skull pin placement in neurosurgical procedures

To compare efficacy of addition of dexmedetomidine or placebo to ropivacaine scalp block to attenuate the hemodynamic response to skull pin placement in neurosurgical procedures

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/08/020826
Enrollment
60
Registered
2019-08-21
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: C71- Malignant neoplasm of brain

Interventions

Intervention1: dexmedetomidine 1 microgram per kg is added to 25 ml 0.5% ropivacaine and solution is made to 30 ml: dexmedetomidine 1 microgram per kg is added to 25 ml 0.5% ropivacaine scalp block to

Sponsors

Department Of Anesthesiology and Critical Care
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of either sex Patients aged 18 to 65 years American Society of Anesthesiologists physical status grade I and II Patients scheduled for elective neurosurgical procedures under general anesthesia with tracheal intubation

Exclusion criteria

Exclusion criteria: Patients with uncontrolled hypertension Patients with preoperative bradycardia, ischemic heart disease, cardiac arrhythmias Patients with severe hepatic and renal disease Patients with past history of craniotomy Patients allergic to study drugs Patients on alpha blockers treatment preoperatively Patient refusal Patient unable to give consent Pregnant women and lactating mothers

Design outcomes

Primary

MeasureTime frame
Heart rate , systolic blood pressure , diastolic blood pressure and mean arterial pressure are measured at different time points following skull pin placement .Timepoint: Heart rate , systolic blood pressure , diastolic blood pressure and mean arterial pressure are measured at 1 3 5 10 minutes following skull pin placement

Secondary

MeasureTime frame
2. Number of episodes of hypertension, hypotension, bradycardia and tachycardiaTimepoint: during study period.

Countries

India

Contacts

Public ContactDr Aloka Samantaray

Sri Venkateshwara Institute Of Medical Science

aloksvims@gmail.com9493547653

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026