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Will drug delivery through electricity have fewer side effects compared to oral drug in hand foot allergy?

Will methotrexate iontophoresis have fewer side effects compared to oral methotrexate in treatment of palmoplantar hyperkeratotic eczema?

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/08/020770
Enrollment
49
Registered
2019-08-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L309- Dermatitis, unspecified

Interventions

Intervention1: Methotrexate delivery through Iontophoresis : Iontophoresis using Methotrexate solution will be carried on study palm/ sole with injectable preparation of Methotrexate (50mg /2ml) once

Sponsors

SELF
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of age 18-60 years and consenting for the study. Patients having palmoplantar hyperkeratotic eczema predominantly, having lesions of duration more than 8 weeks.

Exclusion criteria

Exclusion criteria: Non consenting patient. Pregnant and lactating females Patient with hematological, renal, hepatic disorder and having malignancy. Patient those on pacemakers ,cardiac arrhythmias, metallic implanted devices in the area current flows or intrauterine metallic implantations . Hypersensitivity to previous methotrexate. Patient who are on other immunosuppresive agent. Patient who had been on systemic or topical steroids for >2 months. Patients of palmoplantar hyperkeratotic eczema with proven allergen will be excluded.

Design outcomes

Primary

MeasureTime frame
Side effects both local and systemicTimepoint: 3 months

Secondary

MeasureTime frame
Cure of the disease by HECSITimepoint: 3 MONTHS

Countries

India

Contacts

Public ContactSuvigya Sachan

Kalinga Institute Of Medical Sciences

basantikumari.devi@kims.ac.in9439549249

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026