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Comparing diabetes in Indians and Swedish.

Mother, father, child and diabetes risk: interplay between genes and environment in India and Sweden. A transethnic study of parent-of-origin effects in fetal programming of diabesity using â??omics approaches

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/08/020768
Enrollment
8000
Registered
2019-08-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E118- Type 2 diabetes mellitus with unspecified complications

Interventions

None listed

Sponsors

Department of Science and Technology
Lead Sponsor
Swedish Research Council
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: For objective 1 This is a secondary analysis on data collected on Indian T2D patients (WELLGEN study) and Swedish Data will come from the Swedish cohort ANDIS of T2D patients from Sweden. WELLGEN contains T2D patients diagnosed below 45 years of age (n 1500) and diagnosed more than 45 years of age (n 1500), ANDIS has data on more than 8000 T2D patients. Extensive phenotypic and genotypic data has been collected on all patients with appropriate EC permission and individual consent. For objective 2 The data will come from multiple cohort studies from the repository of the Diabetes Unit, KEM Hospital (PMNS, PCS, CRISIS, WELLGEN etc.). We will include data from healthy volunteers as well as T2DM patients on whom extensive phenotypic data (Anthropometry, Body composition and biochemistry) is available. For objective 3 This is an analysis based on omics data available in public domain databases. We will search with standard search engines GEO datasets, NCBI, GTEX, EMBL. WE will preferably select papers providing data on more than 20 samples. Our preference will be for transcriptomics (RNA-Seq, microarray data). a. Disease type : T2D b. Tissue type : pancreas, serum , placenta; single cell or whole organ.

Exclusion criteria

Exclusion criteria: For objective 1 Patients suspected of T1D , secondary diabetes and monogenic diabetes are excluded. Extensive phenotypic and genotypic data has been collected on all patients with appropriate EC permission and individual consent. For objective 2 NIL For objective 3 a. Type 1 diabetes, cancer and other pathologies. b. datasets on other omics i.e. methylation , metabolomics.

Design outcomes

Primary

MeasureTime frame
Comparative description of T2D characteristics in Indians and Swedes (genetic, parent of origin effects, and phenotypes including physical characteristics, glucose insulin relationships and associated factors (lipids, blood pressure, and organ damage)Timepoint: 0 to 18 months—

Secondary

MeasureTime frame
1. Genotype â?? phenotype association differences in Indians and Swedes for classic genes like FTO , TCF7alpha , KCNQ1 etc .Timepoint: 0 to 18 months;2. Tissue-specific (pancreatic) compendium of â??omics catalogues and mathematical modeling to predict life course.Timepoint: 0 to 24 months—

Countries

India, Sweden

Contacts

Public ContactDr Chittaranjan S Yajnik

Diabetes Unit, KEM Hospital Research Centre

csyainik@gmail.com02026061958

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026