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Mitochondria-targeted Pyrroloquinoline quinone (PQQ)can be a potential therapeutic in progressive respiratory diseases.

Microbial origin mitochondria-targeted nutraceutical therapy in progressive respiratory diseases

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/08/020762
Enrollment
Unknown
Registered
2019-08-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J60-J70- Lung diseases due to external agents

Interventions

Control Intervention1: NIL: NIL

Sponsors

CSIR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: • Patients with a clinical and / or radiological diagnosis of COPD and ILD in the Pulmonary medicine OPD and clinics. • Definition of COPD: (a common preventable and treatable disease characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. Exacerbations and comorbidities contribute to the overall severity in individual patients). Classification of severity will be done based on GOLD 2018 criteria using spirometry according to ATS / ERS recommendations (2005). • Definition of ILD: (patients with diagnosis of ILD based on clinical features, spirometry and radiological (HRCT chest) basis. All types of ILD will be included. Adult subjects

Exclusion criteria

Exclusion criteria: 1. Patients other diseases such as lung cancer or pulmonary tuberculosis will be excluded from this study. 2. Pregnant women will be excluded from this study. 3. Patients not willing to give consent will be excluded.

Design outcomes

Primary

MeasureTime frame
The primary outcome of this program is at least one drug candidate (new or repurposed) at an advanced level of development (efficacy in human trial or large animal). The program will also build capacity and enhance scientific understanding of respiratory diseases.Timepoint: 6 months

Secondary

MeasureTime frame
Upon successful completion of the project, give a potential therapeutics for respiratory disease like COPD and IPF.Timepoint: 6 months

Countries

India

Contacts

Public ContactAnant Mohan

All India Institute of Medical Sciences

anantmohan@yahoo.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026