Health Condition 1: H160- Corneal ulcer
Conditions
Interventions
Intervention1: Linezolid 0.2%: Use this drop in patients of pythium keratits.
Topically every hourly for 2 weeks followed by 2 hourly till the time of resolution
Control Intervention1: combination th
Sponsors
LV Prasad Eye Institute
Eligibility
Inclusion criteria
Inclusion criteria: 1.All cases with microbial keratitis confirmed on smears and/or culture as Pythium by Microbiologist. 2.Size of infiltrate less or equal to 8 mm excluding the tentacles. 3.Had not used previously Azithromycin or linezolid 4.Ready to give consent 5.Consent for regular follow-up 6.More than 18 years
Exclusion criteria
Exclusion criteria: 1.Mixed infection on smears or cultures 2.Known Allergy to Linezolid or Azithromycin 3.Size of infiltrate > 8 mm 4.Not willing to come for regular follow-up or admission or giving consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ulcer completely resolved on medical therapy or application of tissue adhesive for thinning.Timepoint: Ulcer completely resolved on medical therapy or application of tissue adhesive for thinning. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of patients undergone therapeutic Penetrating keratoplasty (TPK) for worsening of infection.Timepoint: 1 month, 3 months and 6 months | — |
Countries
India
Contacts
Public ContactDrBhupesh Bagga
LV Prasad Eye Institute
Outcome results
None listed