comparative study of adjuvant to epidural bupivacaine for post operative pain relief in adult patients undergoing total knee replacement

Comparative study of dexmedetomidine and fentanyl as an adjuvant to epidural bupivacaine for post operative pain relief in adult patients undergoing total knee replacement:A Randomized Study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/08/020706

Enrollment

Registered

2019-08-14

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M17- Osteoarthritis of knee

Interventions

Intervention1: Dexmedetomidine: study of dexmedetomidine as a adjuvant in epidural anaesthesia for postoperative pain relief in adult patients undergoing total knee replacement Inj .5% Bupivacaine pla

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and II patients Patients undergoing total knee replacement surgeries

Exclusion criteria

Exclusion criteria: Patients with mental dysfunction or cognitive deficiency history of psychiatric illness Patients with neuro-muscular, vestibular, hepatic or major systemic disease History of alcohol or drug abuse History of allergy to local anaesthetics Patients with any contraindications to epidural anaesthesia medical conditions affecting balance and coordination

Design outcomes

Primary

Measure	Time frame
Evaluate and Compare the anaesthetic effects and post-operative pain relief of epidurally administered bupivacaine plus fentanyl with Bupivacaine plus dexmedetimidineTimepoint: 1yr	—

Secondary

Measure	Time frame
Evaluate and Compare the anaesthetic effects and post-operative pain relief of epidurally administered bupivacaine plus fentanyl with Bupivacaine plus dexmedetimidineTimepoint: 1yr	—

Countries

India

Contacts

Public ContactSana Naseem

Jawaharlal Nehru Medical College AMU Aligarh

drabunadeem@gmail.com9837757772

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026