Health Condition 1: O94-O9A- Other obstetric conditions, not elsewhere classified
Conditions
Interventions
Intervention1: Endometrial biopsy,
Endometrial fluid aspiration,
Blood sample collection: We will be collecting the part of the endometrial biopsy during the time of mock transfer on the day 21st of t
Sponsors
NIRRH
Manipal Academy of Higher Education
Eligibility
Inclusion criteria
Inclusion criteria: For idiopathic recurrent implantation failure o Women o Normal hysteroscopy finding o Two or more prior embryo transfer have failed to implant despite having good endometrial thickness ( >7 mm) o History of cumulative transfer of more than 4 good quality embryos (without chromosomal abnormalities etc.) o Have opted for IVF/ICSI due to unexplained infertility For the control group o Regularly cycling women between 20 to 40 years undergoing IVF/ICSI due to male factor infertility or women opting for interval tubal ligation o Women with normal pelvic scan and normal hormone profile o Women with no history of systemic or gynaecological diseases o Women who are not using hormonal contraceptives
Exclusion criteria
Exclusion criteria: For idiopathic recurrent implantation failure o Women with a history of endometriosis, PCOS, fibroids and systemic or pelvic pathologies, autoimmune disorders, gout, atherosclerosis or other inflammatory disorders. o Women who have been treated with non-steroidal anti-inflammatory drugs (NSAIDs) for less than seven days prior to endometrial sampling. For the control group o Women with a history of endometriosis, PCOS, fibroids and systemic or pelvic pathologies, autoimmune disorders, gout, atherosclerosis or other inflammatory disorders. o Women who have been treated with non-steroidal anti-inflammatory drugs (NSAIDs) for less than seven days prior to endometrial sampling.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gain a comprehensive view of uterine micro-environment in women with idiopathic recurrent implantation failureTimepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Immunophenotype of endometrial samples from women with RIFTimepoint: 3 years;the expression of key endometrial molecules reported to be involved in embryo adhesion, invasion and decidualization in women with RIFTimepoint: 3 years;Whether the receptive phase uterine secretome differs in women with RIF as compared to that of healthy womenTimepoint: 3 years | — |
Countries
India
Contacts
Public ContactDR GEETANJALI SACHDEVA
ICMR NIRRH
Outcome results
None listed