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effect of two drugs (ketamine or dexmedetomidine) on motor evoked potential used to monitor spinal cord function during spine surgery

Effect of Ketamine or Dexmedetomidine with Propofol infusion on transcranial electrical motor evoked potential among patients undergoing spine surgery - a prospective randomized exploratory study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/08/020645
Enrollment
90
Registered
2019-08-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M958- Other specified acquired deformities of musculoskeletal system

Interventions

Intervention1: nil: nil Control Intervention1: to assess the effect of ketamine, dexmedetomidine on latency and amplitude of motor evoked potential: After inducing and intubating the patient following

Sponsors

department of anaesthesiology and critical care
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 2. ASA- I and III 3. Patients undergoing spine surgery ( intraspinal tumors, tethered spinal cord, spinal cord stenosis, fracture of the vertebral body, scoliosis correction, ossification of the posterior spinal ligament ) with TceMEP monitoring 4. Patients with bilateral upper and lower limb motor function >=4/5 grade of Medical Research Council (MRC) Scale

Exclusion criteria

Exclusion criteria: 1. severe cardiovascular diseases (such as heart block, heart failure, left ventricular dysfunction) 2. significant pulmonary, renal, hepatic or neuromuscular disease, 3. contraindications for MEP monitoring such as epilepsy, cortical lesion, raised intracranial tension, cardiac diseases, intracranial electrodes, vascular clips/shunts, 4. history of chronic alcohol use 5. Anaemia , Hb 6. defined allergy to any of study drugs 7. BMI >30 kg/m2

Design outcomes

Primary

MeasureTime frame
1. To assess the effect of ketamine and dexmedetomidine infusion on amplitude of MEP 2. To assess the effect of ketamine and dexmedetomidine infusion on latency of MEP Timepoint: intraoperative period at 30 minutes interval and at the end of surgical intervention—

Secondary

MeasureTime frame
1. Changes in perioperative hemodynamic parameters 2. Dosage of propofol used 3. Total opoids requirement in intraoperative period 4. Effect on extubation parameter in term of Emergence and extubation time 5. Pain assessment in postoperative period and postoperative analgesic requirement for 1st 24 hours 6. Post operative complications if any Timepoint: in intraoperative and postoperative period—

Countries

India

Contacts

Public ContactRoshan Andleeb

AIIMS, rishikesh

sanjay.anaes@aiimsrishikesh.edu.in6397086467

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026