comparison of two parameters, one derived from an inra arterial line and another derived from pulse oximeter to guide fluid therapy in patients undergoing elective surgery for brain tumours

Comparison of stroke volume variation (SVV) and plethysmography variability index (PVI) in guiding goal directed fluid therapy (GDFT) in patients undergoing elective craniotomy for supratentorial brain tumours - an equivalence trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/08/020639

Enrollment

Registered

2019-08-09

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G938- Other specified disorders of brain

Interventions

Intervention1: Goal directed fluid therapy guided either by stroke volume variation or plethysmography variability index: Goal directed fluid therapy in patients undergoing elective craniotomy for sup

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade 1 and 2 patients posted for elective craniotomy for supratentorial brain tumours

Exclusion criteria

Exclusion criteria: Cardiac arrythmias, severe valvular heart disease, left ventricular dysfunction, pathological lung conditions, hemoglobinopathies, chronic kidney disease

Design outcomes

Primary

Measure	Time frame
Total volume of fluid administered intraoperativelyTimepoint: end of the surgery	—

Secondary

Measure	Time frame
Serum lactate levels, serum creatinine levels, brain relaxation score, correlation between stroke volume variation and plethysmography variability indexTimepoint: Serum lactate levels will be measured prior to induction of anaesthesia and then at hours 2,4,6,8 and so on till the end of the surgery.it will also be measured at 24 hours after the surgery. serum creatinine will be measured the day before surgery, at 24 hours after the surgery and on post operative day 5, brain relaxation score will be assessed by the surgeon at the time of dural opening and during dural closure, correlation between SVV and PVI will be measured during statistical analysis	—

Measure

Time frame

Serum lactate levels, serum creatinine levels, brain relaxation score, correlation between stroke volume variation and plethysmography variability indexTimepoint: Serum lactate levels will be measured prior to induction of anaesthesia and then at hours 2,4,6,8 and so on till the end of the surgery.it will also be measured at 24 hours after the surgery. serum creatinine will be measured the day before surgery, at 24 hours after the surgery and on post operative day 5, brain relaxation score will be assessed by the surgeon at the time of dural opening and during dural closure, correlation between SVV and PVI will be measured during statistical analysis

—

Countries

India

Contacts

Public ContactAnkita Dey

JIPMER

drprasannabidkar@gmail.com9442706168

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026