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The effect of end of expiration Positive Pressure on Central Venous Pressure in patient with closed and open chest undergoing cardiac surgery

Quantitative effect of Positive End Expiratory Pressure on Central Venous Pressure in patient with closed and open thorax

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/08/020633
Enrollment
62
Registered
2019-08-08
Start date
Unknown
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I39- Endocarditis and heart valve disorders in diseases classified elsewhere Health Condition 2: I361- Nonrheumatic tricuspid (valve) insufficiency Health Condition 3: I52- Other heart disorders in diseasesclassified elsewhere

Interventions

Intervention1: Three different levels of Positive end expiratory pressures (0cm H2O, 5cm H2O and 10cm H2O): Three different levels of Positive end expiratory pressure 0cm H2O, 5cm H2O and 10cm H2O wil

Sponsors

Jawaharlal Institute of Postgraduate Medical Education and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18-60 years undergoing elective cardiac surgery of American Society of Anaesthesiologists (ASA) physical status I, II and III

Exclusion criteria

Exclusion criteria: 1. Patient with preexisting history of chronic obstructive pulmonary diseases, acute respiratory distress syndrome, Emphysematous diseases, arrhythmias 2. Patient with documented Pulmonary vein stenosis, any obstruction at right ventricular outflow tract, pulmonary artery, pulmonary vein.

Design outcomes

Secondary

MeasureTime frame
a.To assess the quantitative effect of positive end expiratory pressure on different levels of baseline central venous pressure. b. To compare the effect of increase in positive end expiratory pressure on change in central venous pressure in patients with or without tricuspid regurgitation.Timepoint: a.The baseline central venous pressure will be noted. The corresponding central venous pressure will be measured following 2 min of application of positive end expiratory pressures at every 15 second for next 1 minute. b.The presence or absence of tricuspid regurgitation will be measured with transesophageal echocardiography before start of procedure. The corresponding central venous pressure will be measured.

Primary

MeasureTime frame
To assess the quantitative effect of positive end expiratory pressure on change in central venous pressure in patients with closed thorax compared to open thorax in patient undergoing cardiac surgery. Timepoint: Three different levels of positive end expiratory pressure (0 cm H2O, 5cm H2O and 10cm H2O) will be applied to the patient before sternotomy and after sternotomy. The central venous pressure will be measured following 2 min of application of positive end expiratory pressure at every 15 second for next 1 minute. The mean value of 4 readings obtained will be calculated and documented.

Countries

India

Contacts

Public ContactDr Lalit Jha

Jawaharlal institute of postgraduate medical education and research

sumanlatagupta13@gmail.com9488830091

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026