Health Condition 1: O- Medical and Surgical Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Intranasal Dexmedetomidine: Dexmedetomidine (1µgkg-1), nasal instillation, 30 minutes before induction of anaesthesia.
Control Intervention1: Intravenous Dexmedetomidine: Dexmedetomidi
Sponsors
VMMC and Safdarjung Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1.Adult patients (18-65 years), of either sex, having ASA physical status I 2.Undergoing elective surgery under general anaesthesia with tracheal intubation.
Exclusion criteria
Exclusion criteria: 1.Patients having any nasal pathology 2.Predicted difficult laryngoscopy/ intubation 3.Pregnancy 4.Known allergy to study medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the efficacy of intravenous with intranasal dexmedetomidine for attenuation of haemodynamic response to laryngoscopy and tracheal intubation with regard to heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure at various time pointsTimepoint: Haemodynamic parameters heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure), oxygen saturation (SpO2) and end tidal carbon dioxide (EtCO2) will be recorded at 1.baseline 2.after nasal pre-medication (at 10 and 20 min), 3. 5 and 10 min of intravenous infusion of study drug/pre-induction, 4.post-induction, 5. 3 min post induction 6. post-intubation (at 1,3,5 and 10 min) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Pre-induction sedation score 2. Induction dose of propofolTimepoint: 1.Sedation score (Ramsay sedation score) will be recorded at a)baseline in the pre-operative area b)before induction of anaesthesia c) at recovery. 2.Induction dose of propofol required until loss of verbal contact will be noted at the time of injecting propofol | — |
Countries
India
Contacts
Public ContactDr Anjali Kochhar
VMMC and Safdarjung Hospital
Outcome results
None listed