Health Condition 1: B509- Plasmodium falciparum malaria, unspecified
Conditions
Interventions
Intervention1: NIL: NIL
Sponsors
ICMR
Eligibility
Inclusion criteria
Inclusion criteria: Mono infection with P falciparum detected by microscopy parasitaemia of 1000 to 100000 per µl asexual forms presence of axillary more or equal to 37.5 °C or history of fever during the past 48 h ability to swallow oral medication ability and willingness to comply with the study protocol for the duration of the study and to comply with the study visit schedule; and Informed consent from the patient or from a parent or guardian in the case of children.
Exclusion criteria
Exclusion criteria: presence of general danger signs in children aged under 5 years or signs of severe falciparum malaria according to the definitions of WHO mixed or mono-infection with another Plasmodium species detected by microscopy presence of severe malnutrition presence of febrile conditions due to diseases other than malaria (e.g. measles, acute lower respiratory tract infection, severe diarrhoea with dehydration) or other known underlying chronic or severe diseases regular medication, which may interfere with antimalarial pharmacokinetics history of hypersensitivity reactions or contraindications to any of the medicines being tested or used as alternative treatment and a positive pregnancy test or breastfeeding; unable to or unwilling to take contraceptives for women of child-bearing age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To observe the evidence of artemisinin resistance in P falciparum malaria in eastern India. Efficacious antimalarial medicines are critical to malaria control. Continuous monitoring of their efficacy is needed to inform treatment policies in malaria-endemic countries, and to ensure early detection of, and response to, drug resistanceTimepoint: 28 days followup period | — |
Secondary
| Measure | Time frame |
|---|---|
| To observe Kelch13 mutationTimepoint: 28 days | — |
Countries
India
Contacts
Public ContactDr Anupkumar Anvikar
ICMR National Institute of malaria Research
Outcome results
None listed