Comparative trial of two topical preparations in palmoplantar psoriasis

A randomised, double-blind, comparative trial of topical Methotrexate 1% gel along with topical urea emollient versus topical Clobetasol propionate 0.05% ointment along with topical urea containing emollient in mild to moderate variety of palmoplantar psoriasis - METCLOP

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/08/020569

Enrollment

Registered

2019-08-06

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L408- Other psoriasis

Interventions

Intervention1: Topical Methotrexate 1% gel AND Urea containing emollient: Topical Methotrexate 1% gel twice daily plus AND Urea containing emollient twice daily, for 12 weeks Control Intervention1: To

Eligibility

Inclusion criteria

Inclusion criteria: Males and females aged 18 to 80 years, with mild to moderate palmoplantar psoriasis

Exclusion criteria

Exclusion criteria: Pregnant and nursing females Patients with Diabetes, malignancy, hepatic and renal dysfunction History of hypersensitivity to any drug Those previously treated for psoriasis in last 3 months Patients not willing to comply with protocol requirements

Design outcomes

Primary

Measure	Time frame
Number of lesions Erythema Scaling PASI scoreTimepoint: Week 0,2,4,6,8,10,12	—

Secondary

Measure	Time frame
Quality of Life (DLQI)Timepoint: Week 0,2,4,6,8,10,12	—

Countries

India

Contacts

Public ContactAnupam Das

Department of Dermatology, KPC Medical College and Hospital

senguptasujata@yahoo.co.in9830165267

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026