Health Condition 1: N170- Acute kidney failure with tubularnecrosis
Conditions
Interventions
Intervention1: Amino acid infusion to assess the renal reserve: Aminoacid infusion (10%) will be given at the rate of 4 ml/KBW over a period of 3 hours in patients who have a normal e GFR and uACR , 3
Sponsors
Jawaharlal Institute of postgraduate Medical Education Research
Eligibility
Inclusion criteria
Inclusion criteria: All dialysis requiring patients with AKI (defined as more than or equal to 1.5 times increase in the baseline creatinine within 7 days or more than or equal to 0.3mg/dl increase from the baseline creatinine within 48hours or urine output of less than 0.5ml/kg/hr for 6 hours )
Exclusion criteria
Exclusion criteria: 1. CKD stage 5d (eGFR 2. Obstructive uropathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To assess the tubular recovery in patents with dialysis requiring AKI with urinary TIMP2(Tubular inhibitor of metalloproteinase 2) and IGFBP-7(Insulin like growth factor binding protein-7) as candidate markers 2. To assess the renal reserve in patients who show a complete recovery of AKI (eGFR60ml/min and uACR of 30 at 3 months after the onset of AKI) Timepoint: Outcomes will be assessed at 3 months from onset of Acute Kidney Injury | — |
Secondary
| Measure | Time frame |
|---|---|
| To correlate the renal injury markers and renal reserve with eGFR at 1 year following AKITimepoint: One year | — |
Countries
India
Contacts
Public ContactDr Sejpal Kapil Navin
Jawaharlal Institute of postgraduate Medical Education & Research
Outcome results
None listed