Pressure changes of the tube used for providing breaths to the patients during anaesthesia with useage of various gases

A comparative study of cuff pressure changes of endotracheal tube with the use of air versus nitrous oxide in the anaesthetic gas mixture during laparoscopic surgeries - ETANOLS

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/08/020558

Enrollment

Registered

2019-08-05

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis Health Condition 2: N971- Female infertility of tubal origin Health Condition 3: K358- Other and unspecified acute appendicitis Health Condition 4: K409- Unilateral inguinal hernia, without obstruction or gangrene Health Condition 5: N19- Unspecified kidney failure

Interventions

Intervention1: Nitrous oxide: Nitrous oxide will be given from the beginning of surgery till the end via gaseous mixture through the endotracheal tube to reach the lungs Control Intervention1: Air: Ai

Eligibility

Inclusion criteria

Inclusion criteria: Patients coming under American Society of Anaesthesiologists(ASA) Grade 1 and Grade 2 Patients undergoing laparoscopic abdominal surgery Patients between 18-70 years of age Both male and female gender

Exclusion criteria

Exclusion criteria: Patients having preoperative sore throat Patients with preoperative upper and lower respiratory tract infections Patients with oropharyngeal pathology Patients with laryngeal disease or laryngeal surgery Patients with anticipated difficult intubation

Design outcomes

Primary

Measure	Time frame
PRIMARY OBJECTIVE: The primary objective of the study is to compare the effect of group 1 using air oxygen mixture versus group 2 using nitrous oxide oxygen mixture in the anaesthetic gas mixture on endotracheal cuff pressure by the measurement of endotracheal tube cuff pressure during laparoscopic surgery Timepoint: change in cuff pressure for every 30 minutes	—

Secondary

Measure	Time frame
The secondary objective is to observe the occurrence of postoperative complications like sore throat,hoarseness and dysphagia caused by the increased endotracheal tube cuff pressure in the first 24 hours.Timepoint: sore throat grading for 24 hours	—

Countries

India

Contacts

Public ContactMAMIE ZACHARIAH

PONDICHERRY INSTITUTE OF MEDICAL SCIENCES

mamiezac@gmail.com8344252595

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026