Personalising the ventilator settings to the patient by a simple measure of pressure in their foodpipe(esophagus) during a surgery

Effect of Transpulmonary Pressure guided PEEP titration on post-operative oxygenation parameters compared to conventional PEEP application in patients undergoing Laparoscopic Pelvic surgery: An Open Label Randomised Controlled Trial

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/08/020556

Enrollment

Registered

2019-08-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K00-K95- Diseases of the digestive system Health Condition 2: N00-N99- Diseases of the genitourinary system

Interventions

Intervention1: Titrating the PEEP according to Transpulmonary pressure: While still in the supine position esophgeal balloon catheter (MBMED Fluxmed GrT) will be inserted and its position will be conf

Eligibility

Inclusion criteria

Inclusion criteria: - American society of Anaesthesiologists physical status I and II - Scheduled for laparoscopic pelvic surgery

Exclusion criteria

Exclusion criteria: - Refusal to participate - Coexisting pulmonary, cardiovascular or oesophageal pathology - Previous oesophageal or pulmonary operation - Patient BMI less than 18 or BMI more than 30

Design outcomes

Primary

Measure	Time frame
To compare the effect of TPP guided PEEP application and conventional PEEP application (at 5cm H2O) on postoperative oxygenation parameters (PaO2/FiO2 ratio, A-aDO2, and SpO2)Timepoint: Baseline, 15 min post pneumo peritoneum, 15 min post Trendelenburg position, 30 min post shifting to Post-op area	—

Secondary

Measure	Time frame
To compare the effect of TPP guided PEEP application on intra-operative hemodynamic parameters of the patient [Mean Blood Pressure (MAP), Heart Rate (HR) and Pulse Pressure (PP)]Timepoint: Baseline, 15 min post pneumo peritoneum, 15 min post Trendelenburg position, 30 min post shifting to Post-op area;To compare the effect of TPP guided PEEP application on intra-operative respiratory mechanical parameters [Lung compliance (CL), Respiratory system Compliance (CRS), Chest wall Compliance (CCW), Lung Elastance (EL), Respiratory system Elastance (ERS), Chest wall Elastance (ECW), Plateau Pressure (PPLAT) and Peak Pressure (PPEAK)]Timepoint: Baseline, 15 min post pneumo peritoneum, 15 min post Trendelenburg position, 30 min post shifting to Post-op area	—

Measure

Time frame

To compare the effect of TPP guided PEEP application on intra-operative hemodynamic parameters of the patient [Mean Blood Pressure (MAP), Heart Rate (HR) and Pulse Pressure (PP)]Timepoint: Baseline, 15 min post pneumo peritoneum, 15 min post Trendelenburg position, 30 min post shifting to Post-op area;To compare the effect of TPP guided PEEP application on intra-operative respiratory mechanical parameters [Lung compliance (CL), Respiratory system Compliance (CRS), Chest wall Compliance (CCW), Lung Elastance (EL), Respiratory system Elastance (ERS), Chest wall Elastance (ECW), Plateau Pressure (PPLAT) and Peak Pressure (PPEAK)]Timepoint: Baseline, 15 min post pneumo peritoneum, 15 min post Trendelenburg position, 30 min post shifting to Post-op area

—

Countries

India

Contacts

Public ContactDr Samarth Agarwal

All India Institute of Medical Sciences, Jodhpur

samarthx@gmail.com8932938707

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026