None listed
Conditions
Interventions
Intervention1: Serratiopeptidase: Serratiopeptidase is a proteolytic enzyme produced by purification from culture of Serratia E-15 bacteria.
Patients will be administered a single postoperative dose o
Sponsors
Pratyasha Kaushik
Eligibility
Inclusion criteria
Inclusion criteria: Patients above 18 years of age. Patients presenting with pain associated with irreversible pulpitis in mandibular molars with no clinical or radiographic signs or symptoms of acute or chronic apical periodontitis. No history of taking analgesics in the previous 12 hours prior to presenting for treatment. Patients presenting with American Society of Anesthesiologists I or II medical history. Patients providing informed consent. Patients who can read and understand the pain scoring criteria.
Exclusion criteria
Exclusion criteria: Presence of any systemic disorder or sensitivity or allergy that prevents the use of Proteolytic enzymes and NSAIDs. Patients having hepatic and renal disorders. Presence of periapical radiolucency and swelling or any other condition that prevents single-visit root canal treatment. Patients having teeth not suitable for restoration, or having serious periodontal disease that render the teeth unsuitable for endodontic treatment. Pregnant or lactating patients. Teeth will be excluded if there is any overestimation of the working length, inadvertent overinstrumentation through the apical foramen, or extension of the root filling material beyond the working length.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serratiopeptidase may prove to be an effective anti-inflammatory and analgesic agent for post-endodontic pain following single visit root canal treatmentTimepoint: Single dose immediately after endodontic treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Serratiopeptidase may prove to be as effective as ibuprofen for post-endodontic pain following single visit root canal treatmentTimepoint: Single dose immediately after endodontic treatment | — |
Countries
India
Contacts
Public ContactDr Pratyasha Kaushik
Army College of Dental Sciences
Outcome results
None listed