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Does mothers fat tissue send messages to the baby?

Adipocyte-Derived Exosomes in the Thin-Fat Indian Baby Paradox (GLOBAL NON-COMMUNICABLE DISEASES AND INJURY ACROSS THE LIFESPAN: EXPLORATORY RESEARCH (R21))

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/08/020505
Enrollment
300
Registered
2019-08-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

None listed

Sponsors

National Institute of Health NIH
Lead Sponsor
Childrens Research Institute Childrens National Health System
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Pregnant women with gestational diabetes and pregnant women with normal glucose tolerance

Exclusion criteria

Exclusion criteria: Exclusion criteria:- Pregnant women with Type 1 or Type 2 diabetes, Hemoglobin less than 9, IVF conception, other pregnancy complications

Design outcomes

Primary

MeasureTime frame
Associations between: 1.maternal and cord blood adipocyte-derived (ADEmiRNA) exosomal microRNAs that target adipogenesis 2. With infant adiposityTimepoint: 1. Exosome extraction: 9 months from start of study 2. miRNA profiling: 3 months after outcome of step 1 3. miRNA data analysis: 8 months—

Secondary

MeasureTime frame
Association of ADEmiRNA expression with intrauterine exposures (i.e. glycemia and vitamin B12 status during pregnancy)Timepoint: Same as primary outcome—

Countries

India

Contacts

Public ContactDr Chittaranjan S Yajnik

Diabetes Unit, KEMHRC, Pune

csyajnik@gmail.com02066037366

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026