Health Condition 1: Q851- Tuberous sclerosis
Conditions
Interventions
Intervention1: Rapamycin gel/ointment: Rapamycin (sirolimus) is a lipophilic macrocyclic lactone which was first isolated from a soil bacterium Streptomyces hygroscopicus in Rapa Nui (Easter Island) i
Sponsors
MGM Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: All patients of facial angiofibroma
Exclusion criteria
Exclusion criteria: Pregnancy, severe illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rapamycin (sirolimus) is a lipophilic macrocyclic lactone. It is used after renal transplantation and is routinely incorporated in drug-eluting stents during cardiac angioplasty. Rapamycin is very poorly water soluble, severely limiting its bioavailability. Currently it is available in the market in two formulations: Rapamycin oral solution and Rapamycin tablet. Effectiveness is measured by Facial Angiofibroma Severity Index (FASI).Timepoint: Patients will be followed up every 2 weeks and investigations will be done every month. | — |
Secondary
| Measure | Time frame |
|---|---|
| There may be treatment related complications e.g erythema, itching, irritation.Timepoint: Topical rapamycin will be discontinued and patient will be started on topical steroid till resolution of complications. | — |
Countries
India
Contacts
Public ContactDr A D Gulanikar
MGM Medical College and Hospital, Aurangabd
Outcome results
None listed