Measures to improving cognitive and non cognitive functions while receiving chemotherapy for cancer of large intestine

Effect of nurse led intervention on cognitive and non cognitive functions and serum TNF alpha levels in patients receiving chemotherapy for colorectal cancers at Tata Memorial Hospital, Mumbai - Cognex

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/07/020433

Enrollment

130

Registered

2019-07-30

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C189- Malignant neoplasm of colon, unspecified

Interventions

Intervention1: Exercise and Vit D supplement: STUDY PARTICIPANTS WILL BE TAUGHT EXERCISE TO BE CARRIED OUT MINIMUM 2.5 HOURS/ WEEK FOR 12 MONTHS FROM THE TIME OF RECRUITMENT AND WILL BE GIVEN VIT D SU

Eligibility

Inclusion criteria

Inclusion criteria: a) Stage II, III CRC (Colorectal cancer) patients b) Patients with primary colorectal cancer receiving adjuvant CT c) Those receiving 5- FU/ capecitabine based chemotherapy d) Not having any previous history of psychotic disorder e) Age group between 18-58 years f) Who can read and write English, Hindi, Bengali and Marathi g) Willing to participate in the study

Exclusion criteria

Exclusion criteria: a) Receiving targeted therapy b) Psychiatric disorder that may affect ability to participate in the study c) Other conditions such as parkinsonism, disturbed thyroid function d) Earlier treatment with systemic anticancer therapy e) Those who have had craneal irradiation f) Receiving drugs such as tryptomer and amitryptylline g) Those with neutropenia, infection/ infected wound, uncotrolled blood sugars and deranged renal profiles

Design outcomes

Primary

Measure	Time frame
I. Primary objectives a) To assess the cognitive and non cognitive function of participants in experimental group before and after planned intervention c) To compare the cognitive function of participants in experimental and control group before and after planned intervention II. Secondary Objectives a) To assess the non- cognitive function and serum TNF alpha levels of participants in control and study group before and after planned intervention Timepoint: 0,3,6,9,and 12 months	—

Measure

Time frame

I. Primary objectives a) To assess the cognitive and non cognitive function of participants in experimental group before and after planned intervention c) To compare the cognitive function of participants in experimental and control group before and after planned intervention II. Secondary Objectives a) To assess the non- cognitive function and serum TNF alpha levels of participants in control and study group before and after planned intervention Timepoint: 0,3,6,9,and 12 months

—

Secondary

Measure	Time frame
a) To assess the non- cognitive function and TNF alpha levels of participants in study and control group before and after planned intervention b) To compare non cognitive functions and serum TNF alpha levels of participants in study and control group before and after planned intervention c) To assess compliance to chemotherapy Timepoint: 0,3,6,9 and 12 months	—

Countries

India

Contacts

Public ContactAnita Richard Dsouza

Tata Memorial Hospital

dsouza.angaikwad@gmail.com9833784429

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026