Health Condition 1: M04- Autoinflammatory syndromes
Conditions
Interventions
None listed
Sponsors
IPGMER and SSKM Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Cases: Adult patients of either gender with a clinical diagnosis of an autoimmune disorder on azathioprine Subjects on azathioprine who developed leukopenia within one year of treatment initiation that necessitated reduction of dose or drug withdrawal Subjects should be willing to give written informed consent regarding study participation Controls shall fulfill all inclusion and exclusion criteria except the occurrence of incidents of leukopenia. They will be age,gender and ethnicity matched.
Exclusion criteria
Exclusion criteria: History of moderate to severe leukopenia in the past History of intake of any drugs that it likely to have effect on haematopoietic stem cells History of leukaemia, lymphoma, myelodysplastic syndorme,
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TPMT gene polymorphisms c238G to C c460G to A and c719A to G and NUDT15 polymorphism c415C to TTimepoint: within 1 week of enrollment DNA extraction will be done | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of TPMT and NUDT15 gene polymorphismsTimepoint: at outcome | — |
Countries
India
Contacts
Public ContactSUPARNA CHATTERJEE
IPGME&R and SSKM hospital,Kolkata
Outcome results
None listed