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To compare efficiency of fentanyl vs low dose ketamine with dexmedetomidine as analgesic in patients with midline incision using IV patient controlled analgesia pump

Analgesic efficacy of fentanyl vs combination of dexmedetomidine with low dose ketamine in Intravenous patient controlled analgesia in patients undergoing exploratory laparotomy with midline incision: a randomised, controlled prospective study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/07/020292
Enrollment
90
Registered
2019-07-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K261- Acute duodenal ulcer with perforation

Interventions

Intervention1: Intravenous PCA with fentanyl @0.4mg/kg/hr of a solution of 5mg/ml in patients undergoing exploratory laparotomy with midline incision: 2 groups of patients undergoing exploratory lapar

Sponsors

Dr RPGMC TANDA
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1and 2 Undergoing exploratory laparotomy BMI 18.5-29.9 Non opioid dependant

Exclusion criteria

Exclusion criteria: Patients refusal Patient with known drug allergy Opioid dependence Hepatic and renal pathologies History of long term usage of NSAIDS Diabetes mellitus and other neuropathic disorders Psychiatric disorders Inability to use PCA pump History of chronic pain History of postoperative nausea and vomiting History of motion sickness

Design outcomes

Primary

MeasureTime frame
To study and compare the quality of postoperative analgesia in two groups. To calculate the amount of drug consumed in each groupTimepoint: VRS less than 4 in 24 hours post operative—

Secondary

MeasureTime frame
To assess the requirement of rescue analgesic. To assess sedation and PONV by different drug combinations To assess patient satisfaction To assess hemodynamic parameters in the post operative period To assess side effects of drug combinations usedTimepoint: PONV 0-1 RSS 1-2 Patient satisfaction score 1-2 at 15min 30 min 1 hr 6 hours 12 hours and 24 hours post operatively—

Countries

India

Contacts

Public ContactDr Ruby Guleria

Dr RPGMC TANDA HP

g.ruby676@gmail.com9459212660

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026