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Compassion of two different types of mechanical ventilation in sick children with severe lung problem

Comparison of High Frequency Oscillatory Ventilation (HFOV) vs Airway Pressure Release Ventilation (APRV) as a Rescue Mode in Pediatric Acute respiratory distress syndrome (PARDS) who fail Conventional Low Tidal volume Ventilation: A Randomised Controlled Trial.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/07/020284
Enrollment
94
Registered
2019-07-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J00-J99- Diseases of the respiratory system

Interventions

Intervention1: High Frequency Oscillatory Ventilation HFOV: â?¢ Carefusion 3100-A ventilators shall be used. â?¢ Starting MAP will be 2 to 5 cm above conventional ventilation MAP. â?¢ Starting amplitu

Sponsors

Director
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Mechanically ventilated patients Meeting PARDS definition (PALICC recommendation, 2015) Failure of conventional low tidal volume ventilation.

Exclusion criteria

Exclusion criteria: Poor respiratory efforts Air leaks Raised intracranial pressure (ICP) Chronic respiratory disease(s) Unstable hemodynamics which remain refractory to maximum resuscitation efforts.

Design outcomes

Primary

MeasureTime frame
number of ventilator free days between two study groupsTimepoint: 28 days—

Secondary

MeasureTime frame
adverse events and contamination rateTimepoint: 28 days;all-cause mortalityTimepoint: 28 days;length of hospital including pediatric intensive care unit (PICU) stayTimepoint: 28 days;neurological morbidityTimepoint: at PICU discharge and at 3 months;organ-failure-free daysTimepoint: 28 days;ventilator related morbidity (oxygenation indices and/or oxygenation saturation indices, PaO2/FiO2 and/or SpO2/FiO2, and mean airway pressure requirement)Timepoint: 28 days—

Countries

India

Contacts

Public ContactDr Ramesh Kumar R

JIPMER

krramesh_iway@yahoo.co.in7373739142

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026