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Multi- Institutional study to re-define the factors determining oral cavity cancer treated with surgery and adjuvant radiotherapy or chemoradiotherapy

Multi-Institutional Oral Cavity Collaborative - MOCCC

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/07/020269
Enrollment
5000
Registered
2019-07-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx Health Condition 2: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx Health Condition 3: null- Non-metastatic patients at diagnosis (Stage I-IVB per AJCC 7th edition staging) treated for squamous cell carcinoma of the oral cavity between 1/1/2005 and 1/1/2015

Interventions

None listed

Sponsors

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients treated at participating institutions for squamous cell carcinoma of the oral cavity treated with primary surgical resection 2. Patients will have undergone primary surgical resection between 1/1/2005 and 1/1/2015 3. Patients will be staged Stage I-IVB per AJCC 7th edition staging. 4. Patients will be age 18 years or older at time of initial surgery.

Exclusion criteria

Exclusion criteria: 1. History of prior radiotherapy to the head and neck 2. Non-squamous histologies of the head and neck will be excluded.

Design outcomes

Primary

MeasureTime frame
This large international collaboration could help generate hypothesis and maybe enable subsequent studies to answer questions that can be asked of a large oral cavity database which could include: 1) Predictors of failure in early stage disease treated with surgery monotherapy 2) Role of chemotherapy in intermediate risk resected disease 3) Risk of contralateral failure in tongue cancer patients 4) Quality surgical metrics and its impact on outcomes Timepoint: At single time point after enrolment

Secondary

MeasureTime frame
NATimepoint: NA

Countries

Australia, India, United States of America

Contacts

Public ContactDr Sarbani Ghosh Laskar

Tata Memorial Centre

sarbanilaskar@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026