Health Condition 1: S063- Focal traumatic brain injury
Conditions
Interventions
Intervention1: Positive End Expiratory Pressure
End Tidal Carbon diOxide: Positive End Expiratory Pressure 5 and 10 cm H2O and End Tidal Carbon diOxide 30 and 40 mmHg
Control Intervention1: Not applic
Sponsors
National Institute of Mental Health and Neurosciences
Eligibility
Inclusion criteria
Inclusion criteria: Age > 18 years Patients admitted to ICU Patients with baseline requirements of FiO2 Haemodynamic stability Focal lesion in the brain
Exclusion criteria
Exclusion criteria: Age Patients with supra-normal requirements of FiO2 and PEEP Patients with ophthalmological conditions (glaucoma or eye trauma) Conditions where rScO2 measurement using NIRS may be unreliable Conditions with persistent midline shift more than pre-op status Baseline ONSD > 6 mm Baseline rScO2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Optic nerve sheath diameterTimepoint: 10 min after change in ETCO2 to 30 and 40 mmHg and PEEP to 5 and 10 cmH2O | — |
Secondary
| Measure | Time frame |
|---|---|
| correlation between rScO2 and ONSDTimepoint: At 10 min of 30 and 40 ETCO2 and 5 and 10 PEEP;Regional cerebral oxygen saturationTimepoint: At 10 min of ETCO2 of 30 and 40 mmHg and PEEP of 5 and 10 cmH2O | — |
Countries
India
Contacts
Public ContactSweatha
NIMHANS, Bangalore
Outcome results
None listed