Study to find out Effect of drug esmolol used to prevent raise in blood pressure and heart rate that happens when patient comes out of anaesthesia at the end of laparoscopic surgeries

Effect of intravenous esmolol used to attenuate hemodynamic response to extubation in laparoscopic surgeries- An interventional study.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/07/020151

Enrollment

100

Registered

2019-07-12

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K353- Acute appendicitis with localizedperitonitis Health Condition 2: K410- Bilateral femoral hernia, with obstruction, without gangrene Health Condition 3: K412- Bilateral femoral hernia, withoutobstruction or gangrene Health Condition 4: K400- Bilateral inguinal hernia, with obstruction, without gangrene Health Condition 5: K402- Bilateral inguinal hernia, withoutobstruction or gangrene Health Condition 6: K800- Calculus of gallbladder with acutecholecystitis Health Condit

Interventions

Intervention1: Intravenous Esmolol: There are two groups, in group one Esmolol 0.5mg/kg, in group two esmolol 1.0mg/kg, will be given intravenously just before extubation. Control Intervention1: Intra

Eligibility

Inclusion criteria

Inclusion criteria: Patients of either gender, Aged between 18 to 65 years, Belonging to ASA-PS I and II, Undergoing elective laparoscopic surgeries requiring general anaesthesia and endotracheal intubation.

Exclusion criteria

Exclusion criteria: Patients not giving consent. Patients with suspected allergy to study drugs (Esmolol). Patient with difficult airway. Patients with history of bronchospasm. Patients with history of bronchial asthma. Patients with history of cardiovascular diseases

Design outcomes

Primary

Measure	Time frame
heart rate, systolic blood pressure, diastolic blood pressure and mean arterial blood pressureTimepoint: before administering the drug, and after administration, just prior to extubation, then 1 ,2, 3 ,4, 5 minute and at 10 minutes following extubation	—

Secondary

Measure	Time frame
adverse events if any will be recordedTimepoint: post administration of drug/placebo;Quality of Extubation - will be scored on 4 point scale of Eshak (0-No cough or strain, 1-Moderate coughing, 2- High degree of coughing or straining, 3-Poor extubation with laryngospasm). Timepoint: post extubation	—

Countries

India

Contacts

Public ContactDr Kshama S A

Kasturba Medical College, Manipal

drlaxmishenoy@gmail.com9448911261

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026