Health Condition 1: N468- Other male infertility
Conditions
Interventions
Intervention1: MACS (Magnetic Activated Cell Sorting ): -Semen processing is done by simple wash method.
-The resulted pellet is labeled with Annexin V microbeads followed by separation on MACS column
Sponsors
Oasis center for reproductive medice
Eligibility
Inclusion criteria
Inclusion criteria: 1. DFI > 25% by SCSA method 2. Sperm count > 5mill/ml 3. Female aged 21-38yrs 4. History of poor IVF outcome or recurrent pregnancy loss
Exclusion criteria
Exclusion criteria: 1. Recurrent Genital Tract Infection 2. Smoking 3. BMI > 35 4. Clinical varicocoele 5. Sperm donation 6. Presence of any of the endometrial / uterine factors that affect implantation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blastocyst quality rate – defined as the assessment of blastocyst quality according to Gardners criteria.Timepoint: 5th or 6th day after oocyte pickup | — |
Secondary
| Measure | Time frame |
|---|---|
| Blastulation rate – defined as the proportion of blastocysts formed on D5/6 over the cleaved embryos on D3.Timepoint: 5th or 6th day after oocyte pickup;Implantation rate – Defined as number of gestational sac shown by Ultrasound in gestational week 6 per embryo transferred.Timepoint: 4wks following embryo transfer;Clinical pregnancy rate – Defined as number of Gestational sac with fetal heart rate per embryo transfer cycle at 6-7wks GA.Timepoint: 4-6 wks following embryo transfer;Miscarriage rate – Early loss of pregnancy before the 12th week of pregnancyTimepoint: 12 wks of pregnancy | — |
Countries
India
Contacts
Public ContactPrajna S
Oasis center for reproductive medicine
Outcome results
None listed