Health Condition 1: Z790- Long term (current) use of anticoagulants and antithrombotics/antiplatelets
Conditions
Interventions
Intervention1: Apixaban 2.5 mg PO: Post-discharge apixaban 2.5 mg BID PO in patients undergoing planned surgery for gynaecological cancer and have received antithrombotic prophylaxis with LMWH during
Sponsors
Christian Medical College Vellore
Eligibility
Inclusion criteria
Inclusion criteria: 1) Objective diagnosis of gynaecological malignancy 2) Planned major surgery for gynaecological malignancies 3) Antithrombotic prophylaxis with LMWH administered for 7 ± 2 days after surgery
Exclusion criteria
Exclusion criteria: 1) Age 2) Surgery for non-cancer disease 3) Duration of surgery 4) Pre-existing DVT/PE 5) Other indication for anticoagulant therapy 6) Known cerebral metastases 7) Kidney or liver failure (creatinine clearance 8) Known haemorrhagic diathesis or high risk for bleeding 9) History of intracerebral bleeding or neurosurgery within 6 months 10) History of heparin induced thrombocytopenia 11) Pregnancy or lactation 12) Refusal of informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite of symptomatic objectively confirmed DVT/VTE, asymptomatic ultrasonography-confirmed DVT; DVT/VTE-related death within 30 days from surgery for gynaecological cancerTimepoint: 30 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Major bleedingTimepoint: Entire study period | — |
Countries
India
Contacts
Public ContactDr Abraham Peedicayil
Christian Medical College
Outcome results
None listed