Health Condition 1: N042- Nephrotic syndrome with diffuse membranous glomerulonephritis
Conditions
Interventions
None listed
Sponsors
IPGMER AND SSKM HOSPITAL KOLKATA
Eligibility
Inclusion criteria
Inclusion criteria: 1. Biopsy proven PMN of age group 18-70 years, fulfilling the criteria for immunosuppression therapy . 2. Fulfilling the criteria for immunosuppression therapy - Urinary protein excretion persistently exceeds 4 g/d AND remains at over 50% of the baseline value AND does not show progressive decline during antihypertensive and antiproteinuric therapy during an observation period of at least 6 months or severe disabling or life threatning symptoms related to the nephrotic syndrome. 3. SCr has risen by 30% or more within 6 to 12 months from the time of diagnosis but the eGFR is not less than 25 ml/min per 1.73m2 AND this change is not explained by superimposed complications.
Exclusion criteria
Exclusion criteria: 1. Patients with active infection. 2. Diabetes mellitus. 3. Hepatitis B/C or human immunodeficiency virus infection. 4. Liver function abnormalities. 5. Neoplasia. 6. Chronic Diarrhoea. 7. Pregnancy. 8. Patients not willing for contraception.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a) Non inferiority of individual cohorts in inducing complete or partial remission in proteinuriaTimepoint: 1 YEAR | — |
Secondary
| Measure | Time frame |
|---|---|
| a) Sensitivity of anti PLA2R Ab in predicting partial or complete remission in 3 arms at 6 /12/24/30 months of initiation of therapy. b) Estimated glomerular filtration rate (eGFR) at the completion of therapy Timepoint: 1 YEAR | — |
Countries
India
Contacts
Public ContactDr ABHISHEK KUMAR
IPGMER AND SSKM HOSPITAL KOLKATA
Outcome results
None listed