FindTrial
Sign In

A study to compare the effectiveness of dexmedetomidine and ketamine medications administered in mist form into the lungs before surgery in reducing sorethroat following thyroid operations under general anesthesia with endotracheal intubation

A study to compare the efficacy of pre operatively administered nebulised dexmedetomidine and ketamine on reducing post-operative sorethroat in patients following thyroidectomy under general anesthesia with endotracheal intubation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/07/020082
Enrollment
100
Registered
2019-07-08
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group 2: Group 2: patients receiving dexmedetomidine 50 mcg (1ml) with saline(4ml) nebulisation Control Intervention1: Group 1: Group 1: patients receiving ketamine 50 mg (1ml) with sal

Sponsors

Amala Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age group: 18 - 60 years 2. Physical status: ASA physical status 1-2 3. Undergoing thyroidectomy under GA with tracheal intubation.

Exclusion criteria

Exclusion criteria: Patients were excluded if 1. A history of pre-operative sore throat 2. upper respiratory tract infection 3. chronic obstructive pulmonary disease 4. pregnant females 5. Mallampati grade >2 6. known allergies to study drug 7. those who required more than one attempt at intubation

Design outcomes

Primary

MeasureTime frame
Incidence and severity of post op sorethroatTimepoint: at 0,2,4,6,12 and 24 hours after extubation—

Secondary

MeasureTime frame
Incidence of any side effectsTimepoint: at 24 hours post operatively—

Countries

India

Contacts

Public ContactDR DERLIN THOMAS

Amala Institute of Medical Sciences

derlin.t@gmail.com09447768944

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026