To study the efficacy of administration of metformin into thyroid nodules and compare it with oral metformin in patients with benign goiter and normal thyroid function

Comparative evaluation of efficacy of oral versus intranodular administration of metformin on subjects with benign thyroid nodules - CIMET

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/07/020053

Enrollment

Registered

2019-07-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E049- Nontoxic goiter, unspecified

Interventions

Intervention1: Intranodular metformin 1.5 mg- once: Intranodular administration of metformin - 850mg twice daily for 6months Control Intervention1: Oral metformin: Oral metformin

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18 years and above 2. Consecutive patients with thyroid nodules 3. Clinically and biochemically euthyroid

Exclusion criteria

Exclusion criteria: 1. History of intake of levothyroxine/metformin 2. Any ultrasound or FNA evidence of thyroid malignancy 3. Nodules causing compressive symptoms 4. Coalescent thyroid nodules (not suitable for size analysis) 5. HbA1c >7.5% 6. History of significant neurological or psychiatric illness which may influence thyroid function 7. Iodinated contrast exposure within past 6months 8. History of neck irradiation or neck surgery 9. Use of any medication that would affect thyroid functions 10. Pregnancy or lactation 11. Creatinine levels > 1.4 mg/dL 12. Hepatic or cardiac insufficiency 13.History of malignancies

Design outcomes

Primary

Measure	Time frame
Change in the nodule volumeTimepoint: Baseline,at 3 months and at 6 months	—

Secondary

Measure	Time frame
Change in the TSH and thyroid hormones from baseline Timepoint: 6months	—

Countries

India

Contacts

Public ContactAKHIL KRISHNA

IPGMER/SSKM hospital, Kolkata

satinath.mukhopadhyay@gmail.com9830027985

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026