Health Condition 1: J960- Acute respiratory failure
Conditions
Interventions
Intervention1: Metered dose inhaler (MDI) with Spacer: Levosalbutamol sulphate and ipratropium bromide delivered by MDI will be given as four puffs (100 mcg Levosalbutamol/ 20 mcg ipratropium per inha
Sponsors
VMMC and Safdarjung Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Ventilator-dependent patients, in whom the treating physician has ordered bronchodilator aerosols for suspected airways obstruction 2. Age more than 18 years 3. Informed consent available from the legally authorized representative (LAR)
Exclusion criteria
Exclusion criteria: 1. Presence of hypotension (defined as mean arterial BP of 100/min), and/or hemodynamically significant cardiac arrhythmias. 2. A history of symptomatic coronary artery disease in the 6 months prior to admission 3. Patients who have received a short acting bronchodilator in the last 6 hours or a long acting bronchodilator in the last 24 hours 4. Pregnant patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a) Respiratory System Resistance (RRS) b) Peak Expiratory Resistance (RPEAK) c) Peak Pressure (Ppeak) d) Mean Pressure (Pmean) e) Plateau Pressure (Pplat) f) Compliance Dynamic g) Compliance Static h) Delta Airway Pressure (dPAW) i) Peak Inspiratory Flow Rate (PIFR) j) Peak Expiratory Flow Rate (PEFR) k) Ventilator Work of Breathing (WOBV) l) The intrinsicPEEP / autoPEEPAWTimepoint: The measurements will be done at baseline and then at 30 minutes, 60 minutes and 6 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| Additional nebulisation delivered in the 6 hours following administration of levosalbutamol sulphate and ipratropium bromideTimepoint: At the end of 6 hours;Any arrhythmia which requires a change in the treatment of the patientTimepoint: At the end of 6 hours;The arterial blood gas and the serum potassiumTimepoint: The arterial blood gas will be repeated after 6 hours. The serum potassium values will be documented in the following 24 hours after the administration of the bronchodilator.;The Heart rate, BP and the SpO2Timepoint: Will be documented at baseline, 30 minutes, one hour and six hours after the administration.;Time taken to administer the bronchodilator drug (in minutes)Timepoint: At the end of 6 hours | — |
Countries
India
Contacts
Public ContactDr Rohit Kumar
Vardhman Mahavir Medical College and Safdarjung Hospital (VMMC&SJH)
Outcome results
None listed