To guide Mannitol therapy in Traumatic Brain Injury using Ocular Ultrasound.

Optic Nerve Sheath Diameter guided Optimal Mannitol therapy for reduction of Intra Cranial Pressure in Traumatic Brain Injury Patients.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/07/019985

Enrollment

Registered

2019-07-02

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S060- Concussion Health Condition 2: S062- Diffuse traumatic brain injury Health Condition 3: S064- Epidural hemorrhage Health Condition 4: S063- Focal traumatic brain injury Health Condition 5: S061- Traumatic cerebral edema Health Condition 6: S066- Traumatic subarachnoid hemorrhage Health Condition 7: S065- Traumatic subdural hemorrhage

Interventions

Intervention1: Use of ultrasonography to detect rise in ICP.: Optic nerve sheath diameter measured by ultrasound will be used as a surrogate for measurement of ICP to guide mannitol therapy. Control I

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult patients (18 â?? 60 yrs) with an ASA physical status I and II 2. Of either sex 3. History of Traumatic Brain Injury 4. Both patients with or without decompressive surgeries

Exclusion criteria

Exclusion criteria: 1. Patients below 18yrs or above 60yrs 2. Patients with pan-facial trauma 3. Patients with ocular injury 4. Patients with CT or MRI finding suggestive of impending globe rupture

Design outcomes

Primary

Measure	Time frame
To cut down on the ill effects of excess osmotherapy by using a measured approach to intra cranial pressure monitoring.Timepoint: 4hrly ICP monitoring to tailor osmotherapy.	—

Secondary

Measure	Time frame
Intensive ICP monitoring.Timepoint: 4hrly ICP monitoring.	—

Countries

India

Contacts

Public ContactDr Amarendra Kumar Jha

Banaras Hindu University

amarendrajha2013@gmail.com8337007844

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026