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A study to evaluate the role of two additional drugs (Magnesium Sulphate and N-acetyl cysteine) in the treatment of insecticide (organophosphorus) poisoning

Effect of combination of N-acetyl cysteine and Magnesium Sulphate as an adjuvant in the management of Organophosphorous poisoning: A Randomized Clinical Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/07/019970
Enrollment
88
Registered
2019-07-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: T600- Toxic effect of organophosphate and carbamate insecticides

Interventions

Intervention1: NAC and Magnesium Sulphate: Tablet N-acetyl cysteine 600 mg dissolved in 20ml of water and administered through Ryles tube eight hourly for 3 days and Injection Magnesium sulphate 20%

Sponsors

AIIMS Bhubaneswar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of Organophosphorus Poisoning

Exclusion criteria

Exclusion criteria: 1. OP poisoning treatment before coming to AIIMS 2. Multiple poisoning 3. Post cardiac arrest, seizure disorders, Diabetes Mellitus, known Coronary Artery Disease, Respiratory, Renal or Hepatic disease 4. Pregnancy or lactation

Design outcomes

Primary

MeasureTime frame
Reduction of total atropine requirementTimepoint: Daily and cumulatively the end of total ICU stay—

Secondary

MeasureTime frame
Lengths of ICU stay, the need of mechanical ventilation, and mortalityTimepoint: Entire duration of ICU stay—

Countries

India

Contacts

Public ContactDr Jayanta Kumar Mitra

AIIMS Bhubaneswar

anaes_jayanta@aiimsbhubaneswar.edu.in9433798583

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026