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A clinical trial to study the effects of two drugs,Dexmedetomidine and Fentanyl during pneumoperitonium in laproscopic cholecystectomy.

Comparison of effectiveness of intravenous Dexmedetomidine vs fentanyl for attenuation of hemodynamic response to pneumoperitonium in laparoscopic cholecystectomy at SMS College Jaipur During 2018-19: A randomised double blind interventional study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/07/019958
Enrollment
84
Registered
2019-07-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis

Interventions

Intervention1: IV INJ. Dexmedetomidine: 42 patients will receive inj. Dexmedetomidine 1mcg/kg IV diluted with normal saline to make a total volume of 10 ml and injected IV slowly over 10 minute.fol

Sponsors

Department of Anaesthesiology Medical CollegeJaipur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with ASA grade I and II 2.Patients willing to give written informed consent. 3.Age Groups 18 to 50 years 4.Weighing 40 to 70 kg. 5.Scheduled for elective laparoscopic cholecystectomy

Exclusion criteria

Exclusion criteria: 1.Patients not willing to participate in study 2.Patients having history of allergy to anaesthestic agents used in study 3.Patients with pre-existing cardiac disease, Hypertension ,Asthama,Renal or Hepatic dysfunction 4.Patients with anticipated difficult intubation i.e Mallampati class 3 or more,restricted neck movement or restricted mouth opening.

Design outcomes

Primary

MeasureTime frame
To assess and compare the change in hemodynamic variables (HR,SBP,DBP,MAP) after pneumoperitoneum in both the study groups. Timepoint: Data will be recorded Just Before induction,1min after induction,1 min after intubation,3min after intubation,1min after PNP and 10min interval in PNP throughout the surgery and after extubation—

Secondary

MeasureTime frame
1. To assess and compare the duration of post operative analgesia in both the study groups. 2. To determine post-operative sedation level in both the study groups. 3. To determine the incidence of side effects if any in both the study groups.Timepoint: Post-operative sedation level will be measured by using RAMSAY SEDATION SCORE in every 30min. after extubation.POST-OPERATIVE ANALGESIA Evaluated by Visual analogue scale(VAS) in every 30min. upto Giving First Rescue Analgesia.—

Countries

India

Contacts

Public ContactDR CHANDRAKANT PARASHAR

Department of Anaesthesiology,SMS MEDICAL COLLEGE,JAIPUR

reemadrrn@gmail.com9413237117

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026