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A clinical trial to compare the effects of two drugs to maintain blood pressure during cesarean section under spinal anaesthesia

Comparison of Prophylactic Bolus Phenylnephrine versus Bolus Noradrenaline Regimens for Maintaining Hemodynamics During Caesarean Delivery Under Spinal Anaesthesia- An Observational Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/06/019938
Enrollment
102
Registered
2019-06-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O998- Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium

Interventions

Intervention1: Norepinephrine group: Patients will receive prophylactically norepinephrine 8 microg intravenously for treatment of each episode of hypotension till the time of delivery Control Interve

Sponsors

Kasturba Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Healthy females with a term,uncomplicated,singleton pregnancy undergoing elective cesarean section section under spinal anaesthesia 2.ASA physical status l ans ll 3. Patients weighing between 40-100 kg 4. Patients height between 140-180 cm

Exclusion criteria

Exclusion criteria: 1.Hypertension,cardiovascular diseases,renal diseases,diabetes 2.Absolute or relative contraindications for spinal anaesthesia 3.Patients on mono amine oxidase inhibitors or tricyclic antidepressants 4.Allergy or Hypersensitivity to study drugs 5.History suggestive of mesentric or peripheral vascular thrombosis 6. Patients with known fetal abnormalities

Design outcomes

Primary

MeasureTime frame
Efficacy of the drug to maintain blood pressure and heart rate under spinal anaesthesiaTimepoint: till the time of delivery—

Secondary

MeasureTime frame
1.APGAR scores at 1 and 5 min 2. Number of boluses of vasopressor given 3. Number of episodes of hypotension 5. Incidence of tachycardia/bradycardia/arrhythmias/hypertension 6. Incidence of nausea, vomiting, dizziness or any other complicationTimepoint: Till the time of delivery of baby—

Countries

India

Contacts

Public ContactManasa Acharya

Kasturba Medical College,Mangalore

dr.manasa.acharya@gmail.com9986755585

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026