Health Condition 1: G94- Other disorders of brain in diseases classified elsewhere
Conditions
Interventions
Intervention1: intravenous dexmedetomidine infusion: Dexmeditomidine infusion will be administered 1 mcg/kg in 20 min before induction[37]. . After 20 min study drug infusion, all the patients wil
Sponsors
IPGMER SSKM HospitalKolkata
Eligibility
Inclusion criteria
Inclusion criteria: 1.AGEâ??20-55 YRS 2.SEXâ??either sex 3.GCSâ??14-15 4.SURGERYâ??elective intracranial surgery of a supratentorial tumour under general anaesthesia 5.ASAâ??1 to 2 6.BMI-- 7.HR-- >60/ min 8.BPâ??MAP > 80 mm hg 9. Patients or patient party willing to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Predicted difficult intubation 2. Preoperative beta blocker therapy, alpha-methyldopa,clonidine or other alpha2 agonist 3. Contraindication to beta blocker administration 4. Any history of drug abuse 5. Systemic illness such as considerable hepatic ,renal failure 6. Preoperative neurodeficit or aphasia 7. Known allergy to any of study drug 8. Uncontrolled htn, bronchial asthma, dysarrythmia including af, heart failure, cardiovascular complication, 2nd or 3rd degree heart block 9. Any pre operative haemodynamic instability 10. Pregnency 11. Any patient with difficult intubation requiring more than 20 seconds to intubate 12. Any prolonged operation ( duration > 3 hour )
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes in mean arterial pressure and heart rate Timepoint: Basal, 20 min after study drug infusion, After induction and intubation at 30 min interval up to post operative 2 hrs. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Compare the extubation time after withdrawing anesthetic and study drug 2. Pre and postoperative consciousness and sedation by HUDE Score. 3. Compare the total intraopertive propofol and fentanyl requirements 4. Any other side effects like postoperative nausea and vomiting, hypoxia and respiratory depression Timepoint: before study drug before induction 30 min after extubation | — |
Countries
India
Contacts
Public ContactSaikat Niyogi
Bangur Institute of Neurology
Outcome results
None listed