Health Condition 1: V20-V29- Motorcycle rider injured in transport accident
Conditions
Interventions
Control Intervention1: Phenytoin and Fosphenytoin: Phenytoin 5mg/kg/Day in 3 divided doses for seven days.
Fosphenytoin 5mg PE (phenytoin equivalent) /kg/Day in 3 divided doses for seven days
Sponsors
Institute of Medical Sciences BHU
Eligibility
Inclusion criteria
Inclusion criteria: PATIENT WITH HEAD INJURY ADMITTED TO ICU
Exclusion criteria
Exclusion criteria: 1) Age 65years 2) Patients having seizure before administration of studying drugs. 3) Pregnant and lactating female 4) Hepatic and renal failure patients 5) H/O allergic to phenytoin and fosphenytoin. 6) Prior H/O seizure disorder 7) Other anti convulsive and psychotic therapies 8) Acute CNS pathology (Meningitis and Abcess) 9) Acute metabolic derangement (hyponatremia and hypocalcemia) 10) Chronic alcoholic 11) Previous Neurosurgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Observing 1) Incidence of early onset seizure activity within seven days and 2)Time of onset of seizure ( time since drug administration to occurrence of seizure)Timepoint: Daily for seven days in selected patients since drug administration | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessing side effects of Phenytoin and Fosphenytoin while observing studiesTimepoint: Within three months of time limit | — |
Countries
India
Contacts
Public ContactSIVA KUMAR
IMS- BHU
Outcome results
None listed