Comparision of two anaesthetic regimens intravenous (propofol-fentanyl) and inhalation (sevoflurane-fentanyl) in intraoperative and postoperative effects in brain tumor surgery

Comparision of two anaesthetic regimens(Propofol-fentanyl)versus(sevoflurane-fentanyl) on perioperative haemodynamics,operating conditions and immediate postoperative outcomes in patients undergoing elective neurosurgical procedures involving brain tumors

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/06/019768

Enrollment

Registered

2019-06-19

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G93- Other disorders of brain

Interventions

Intervention1: Group 1 patients will be given titrared sevoflurane to keep BIS value 45 to 50: Sevoflurane vaporiser dial concentration titrated according to BIS value between 45-50 and end tidal sevo

Eligibility

Inclusion criteria

Inclusion criteria: patients undergoing elective neurosurgeries for primary brain tumors of age between 18 to 60 years,of either sex, ASA 1 and 2, GCS 14-15

Exclusion criteria

Exclusion criteria: patients with cardiac disease,uncontrolled hypertension,uncontrolled dibetic,COPD,hepatic and renal dysfunction,age less than 18 years,more than 60 years,GCS less than 13,ASA 3 and 4,recurrent tumors,patient who had surgery related complication like vascular injury,massive bleeding,injury to vital structre requiring postop ventillatory support,obese patient

Design outcomes

Primary

Measure	Time frame
Brain relaxtation ,recovery from anaesthesia like time to eye opening,time to obey commands ,time to extubation after discontinuation of anaesthesia,intraoperative haemodynamics,post extubation haemodynamicsTimepoint: Time taken for eye opening,to obey verbal command ,time for extubation after discontinuation of anaesthesia noted,brain relaxtation assesed by neurosurgeon at time of bone reflection,dural reflection,tumor ressection,dural closure assesesd,haemodynamics preop,preinduction,intubation,pinning,postpinning,skin incision,15 min interval till dural closure,at durl closure,subcutaneous tissue,skin,declamping,preextubation,extubation and immediately after extubation upto 1 hour	—

Measure

Time frame

Brain relaxtation ,recovery from anaesthesia like time to eye opening,time to obey commands ,time to extubation after discontinuation of anaesthesia,intraoperative haemodynamics,post extubation haemodynamicsTimepoint: Time taken for eye opening,to obey verbal command ,time for extubation after discontinuation of anaesthesia noted,brain relaxtation assesed by neurosurgeon at time of bone reflection,dural reflection,tumor ressection,dural closure assesesd,haemodynamics preop,preinduction,intubation,pinning,postpinning,skin incision,15 min interval till dural closure,at durl closure,subcutaneous tissue,skin,declamping,preextubation,extubation and immediately after extubation upto 1 hour

—

Secondary

Measure	Time frame
postop side effects pain,PONV,shivering,agitation,convulsion,desaturation.total opoid consumption,total propofol consumption,any bolus dose of propofol and amount,effect site concentration of propofol during induction,intraop period,sevoflurane end tidal concentation and MAC value during intraop periodTimepoint: intraoperative period upto 24 hours after extubation	—

Countries

India

Contacts

Public ContactDr Sashmita kumari Padhy

SCTIMST TRIVANDRUM

kanmanis@sctimst.ac.in9446334711

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026