Health Condition 1: J454- Moderate persistent asthma Health Condition 2: J455- Severe persistent asthma
Conditions
Interventions
Intervention1: Azithromycin: Dosages of drug: Azithromycin will be given as 8-12 mg/kg/dose alternate day for 3 months.
We will use 250 mg tablet of azithromycin. The numbers of tablet to be given as
Sponsors
Jagat Jeevan ghimire
Eligibility
Inclusion criteria
Inclusion criteria: Children of 5-15 years of age with a diagnosis of poorly controlled asthma. Children already diagnosed with asthma and following up regularly in Pediatric Chest Clinic or Pediatric OPD will be eligible for study. Asthma will be diagnosed clinically based on recurrent episodes of airway obstruction (cough, wheezing and /or breathing difficulty) with multiple triggers and reversibility by history or by positive bronchodilator response. Poorly controlled asthma will be defined as childhood Asthma control test (CACT) score of 11 years of age.
Exclusion criteria
Exclusion criteria: 1. Known allergic to macrolides. 2. Known case of liver, kidney, and/or neurological disease, heart disease. 3. Prolonged QTc interval 4. Received azithromycin within last 2 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in Asthma Control Test or Childhood asthma control test scoreTimepoint: change in Asthma Control Test or Childhood asthma control test score by score of 2 points in 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Average number of exacerbations requiring oral steroids and/or hospitalizationTimepoint: 3 months;Change in Fe NOTimepoint: 3 months;change in parameters of spirometryTimepoint: 3 months;change in percentage of neutrophils in sputumTimepoint: 3 months;Percentage of children positive for bacteria in throat swab/total children where throat swab taken and their sensitivityTimepoint: 3 months;To evaluate Asthma control as per GINA 2018 guidelines.Timepoint: 3 months | — |
Countries
India
Contacts
Public ContactDr Kana Ram Jat
Division of Pediatric Pulmonology. Department of Pediatrics,All India Institute of Medical Sciences
Outcome results
None listed