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To study the movement of upper tooth (canine) during orthodontic treatment after injecting a preparation(i-PRF) made out of patients own blood and also study level of enzyme (Alkaline phoshatase) in patients gingival fluid (form of saliva).

Evaluation of Injectable Platelet Rich Fibrin(i-PRF) effect on rate of canine retraction and Alkaline Phosphatase levels : An In-vivo Study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/06/019716
Enrollment
13
Registered
2019-06-17
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M264- Malocclusion, unspecified

Interventions

Intervention1: Injectable platelet rich fibrin (i-PRF): 4ml of i-PRF will be injected in the labial and lingual attached gingiva and oral mucosa of canine in the experimental side in a split mouth stu

Sponsors

Dr Paridhi Gupta
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients between 14-30 years of age and requiring fixed orthodontic treatment with first premolar extraction. 2.Healthy periodontal tissues (no gingival bleeding, probing depth 3.No use of anti-inflammatory drugs in the month preceding the beginning of the study. 4.Patients who will give consent to be a part of the study. 5. No history of previous orthodontic treatment.

Exclusion criteria

Exclusion criteria: 1.Patients with systemic disease or chronic debilitating disease that could interfere with bone metabolism. 2.Patients on long term use of systemic corticosteroids, antibiotics, calcium channel blockers. 3.Patients with cleft lip or palate. 4.Presence of periodontal bone loss or attachment loss. 5.Patients with periodontitis, untreated caries.

Design outcomes

Primary

MeasureTime frame
Measure rate of canine retraction with and without i-PRF. Measure ALP levels in GCF from the sites with and without i-PRFTimepoint: Measure rate of canine retraction at 3 weeks for 2 years Measure ALP levels in GCF at day 0 (before initiation), after 24 hours and after 28 days.—

Secondary

MeasureTime frame
To compare the ALP levels at experimental and control site. To compare the rate of canine retraction at experimental and control site. Timepoint: Measure rate of canine retraction at 3 weeks for 2 years Measure ALP levels in GCF at day 0 (before initiation), after 24 hours and after 28 days.—

Countries

India

Contacts

Public ContactDr Bhagyalakshmi A

JSS Dental college and Hospital

pari_199311@yahoo.com8447204494

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026