Health Condition 1: K729- Hepatic failure, unspecified
Conditions
Interventions
Intervention1: High Volume plasma exchange: Plasma exchange shall be performed at the bedside on the enrolled patients at liver HDU (Department of Hepatology) on three consecutive days, using a contin
Sponsors
Post Graduate Institute of Medical Education and Research Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1. First episode of de-compensation with AARC-ACLF (APASL (Asian Pacific Association for the Study of the Liver) ACLF (Acute on Chronic Liver Failure) Research Consortium (AARC) grade I or II (AARC score 2. No evidence of active infection 3. Willing to give informed consent for the procedure
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Co-existing HCC or extra-hepatic malignancy 3. Microbiological or radiological evidence of active infection 4. Active hemorrhage 5. Multi-organ failure(>= 3 organ failures) 6. APASL-AARC score >10 7. Known allergy to Plasma, Protamine or Heparin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the efficacy (in term of change of clinical grade of severity) and tolerability (in terms of adverse events related to procedure) of standard (one) volume plasma exchange Vs high volume plasma exchange in acute on chronic liver failure patientsTimepoint: Day 0, Day 4, day 30 and day 90 | — |
Secondary
| Measure | Time frame |
|---|---|
| To estimate the effect of different volume exchange procedure on biochemical parameters and Cytokine levels (IL6 IL10 and TNFα) To compare the effect of different volume exchange procedures on 30 & 90 day mortality. Timepoint: Day 0 to day 4 for biochemical and laboratory parameters and day 30 and day 90 for mortality | — |
Countries
India
Contacts
Public ContactRekha Hans
Post Graduate Institute of Medical Education and Research, Chandigarh
Outcome results
None listed